Obagi CLENZIderm M.D. Systems are the only prescription-strength acne treatments that contain a patented, solubilized form of 5% benzoyl peroxide (BPO) to penetrate deep into the follicle and treat acne where it starts. CLENZIderm M.D. Systems are the only prescription-strength acne therapies that contain a solubilized form of 5% BPO designed to penetrate deep into the follicle and clear acne fast.